2-(azidomethyl)-4-chloro-N-methylbenzamide → 2-(aminomethyl)-N-methylBenzamide
反応式
[N:1]([CH2:4][C:5]1[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:6]=1[C:7]([NH:9][CH3:10])=[O:8])=[N+]=[N-]>C(O)C>[NH2:1][CH2:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([NH:9][CH3:10])=[O:8]参加物
3
実験手順
2-(Azidomethyl)-4-chloro-N-methylbenzamide (0.88 g, 3.94 mmol) was dissolved in ethanol (25 mL), degassed, treated with 10% Pd on carbon (80 mg), and put under one atmosphere of hydrogen. After one hour the reaction was filtered through Celite, and concentrated in vacuo to afford 2-(aminomethyl)-N-methylbenzamide as a white solid.
後処理
- customdegassed
- additiontreated with 10% Pd on carbon (80 mg)
- filtrationAfter one hour the reaction was filtered through Celite
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-65161268a57943528c12f6cddeccd3e2
- 出典データセット
- uspto-grants-2008_01
- 特許番号
- US07323460B2
反応ノート
読み込み中…