3-Chloro-5-nitrobenzotrifluoride → 3-Chloro-5-(trifluoromethyl)aniline

HRID 2252836ノート

反応式

HRID 2252836 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>CO.[Ni]>[NH2:8][C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[C:4]([C:11]([F:12])([F:13])[F:14])[CH:5]=1

参加物

4

反応物 1

HCID 502553-Chloro-5-nitrobenzotrifluoride

生成物 1

HCID 30179333-Chloro-5-(trifluoromethyl)aniline

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

92 g (0.408 mol) of 5-chloro-3-trifluoromethyl-nitrobenzene in 1 l of methanol are hydrogenated in the presence of 10.17 g of Raney nickel. The reaction mixture is filtered through Celite/activated carbon and the residue washed with methanol. Concentration of the filtrate by evaporation yields the oily 5-amino-3chlorobenzotrifluoride; 1H-NMR (DMSO-d6) δ 6.80 (m, 3H), 5.92 (s, H2N).

後処理

  1. filtrationThe reaction mixture is filtered through Celite/activated carbon
  2. washthe residue washed with methanol
  3. customConcentration of the filtrate by evaporation

出典と根拠

ORDレコード
ord-6e8688881023485bb2842559666680ff
出典データセット
uspto-grants-2008_01
特許番号
US07323474B2

反応ノート

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