Borane → N-Benzyl-2-(3-bromobenzyl)-morpholine

反応式

C(N1CCO[C@H](CC2C=CC=C(C=CC3C=NC=CC=3)C=2)C1)(OC(C)(C)C)=O.[CH2:29]([N:36]1[CH2:41][CH2:40][O:39][CH:38]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[C:45]([Br:49])[CH:44]=2)[C:37]1=O)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.B>>[CH2:29]([N:36]1[CH2:41][CH2:40][O:39][CH:38]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[C:45]([Br:49])[CH:44]=2)[CH2:37]1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

参加物

反応物 3

HCID 6331Borane

HCID 67073061HCID 67073061、化合物

HCID 67073511N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine

生成物 1

HCID 67073238N-Benzyl-2-(3-bromobenzyl)-morpholine

実験手順

N-Benzyl-2-(3-bromobenzyl)-morpholine was prepared as described for example 71, intermediate (a), but using N-benzyl-2-(3-bromobenzyl)-morpholin-3-one and borane and was isolated as a pale yellow oil.

後処理

customwas isolated as a pale yellow oil

出典と根拠

ORDレコード: ord-350e725d9c094e52a7200113cd1c6d33
出典データセット: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07323466B2

反応ノート

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