Phenolphthalein → (-)-alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid methyl ester

HRID 225313

反応式

HRID 225313 の反応式
Cl.[CH3:2][O:3][C:4](=[O:17])[CH:5]([NH2:16])[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([CH2:13][O:14][CH3:15])[CH:7]=1.[OH-].[K+].C1C=CC2C(C3C=CC(O)=CC=3)(C3C=CC(O)=CC=3)OC(=O)C=2C=1>CO>[CH3:2][O:3][C:4](=[O:17])[CH:5]([NH2:16])[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([CH2:13][O:14][CH3:15])[CH:7]=1

参加物

5

反応物 3

HCID 4764PhenolphthaleinHCID 14797Potassium HydroxideHCID 70585116(-)-alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid methyl ester hydrochloride

生成物 1

HCID 53644499(-)-alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

(-)-α-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid methyl ester hydrochloride is dissolved in a minimum amount of methanol. To this solution is added methanolic potassium hydroxide until a basic reaction to phenolphthalein is observed. The potassium chloride which precipitates is removed and the solvent is removed under vacuum to give a quantitative yield of the title compound.

後処理

  1. customThe potassium chloride which precipitates
  2. customis removed
  3. customthe solvent is removed under vacuum

出典と根拠

ORDレコード
ord-22c0988786fe4376a47651056bc6e2c5
出典データセット
uspto-grants-1980_11
特許番号
US04236002

関連ノート

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