Sulfuric Acid → 1H-Imidazole-4-sulfonic acid, 5-chloro-1-methyl-
反応式
[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][CH:3]=1.[S:8](=O)(=[O:11])([OH:10])[OH:9]>>[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[S:8]([OH:11])(=[O:10])=[O:9]参加物
3
実験手順
33 g (0.28 mol) of 5-chloro-1-methylimidazole in 200 ml of fuming sulfuric acid are heated at 160°-180° C. for 4 hours. After cooling, the reaction mixture is cautiously added to ice. The product crystallizes out from the cold aqueous solution (about 1.5 l). After recrystallizing twice from water, the title compound is obtained in the form of coarse yellowish crystals of melting point 309°-310° C.
後処理
- temperatureAfter cooling
- additionthe reaction mixture is cautiously added to ice
- customThe product crystallizes out from the cold aqueous solution (about 1.5 l)
- customAfter recrystallizing twice from water
出典と根拠
- ORDレコード
- ord-faf639ffcc1645899c5ac0bf829f29fa
- 出典データセット
- uspto-grants-1993_08
- 特許番号
- US05232922
反応ノート
読み込み中…