化工社化工社 化学情報印刷レポート · 研究参考用
Iodine → 5,5-Dimethyl-1-iodo-trans-octen-3-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Trimethylamine oxide | HCID 1145 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Bis(1,2-dimethylpropyl)borane | HCID 192733 | — |
| 反応物 | 5,5-Dimethyl-3-tetrahydropyranyloxy-1-octyne | HCID 53889730 | — |
| 反応物 | Tetrahydrofuranacetic acid water | HCID 86732972 | — |
| 溶媒 | Diglyme | HCID 8150 | — |
| 生成物 | 5,5-Dimethyl-1-iodo-trans-octen-3-ol | HCID 20465606 | — |
反応手順
Treatment of 23.8 g. (0.100 mole) of 5,5-dimethyl-3-tetrahydropyranyloxy-1-octyne (Example 154) successively with 233 mg. of 0.43M disiamylborane in diglyme, 22.5 g. of trimethylamine oxide, 150 ml. of 1N sodium hydroxide, 25.4 g. of iodine, and 900 ml. of 3:1:1 tetrahydrofuran-acetic acid-water as described in Example 151 gives the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04236027 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-659265b1752e4f169bc2cc6c9755395b |
| 出典メモ | uspto-grants-1980_11 |