Acetyl chloride → Methyl-N-acetyl-1-methyl-2-(phenylmethylene)hydrazinecarboximidothioate

反応式

I.[CH3:2][S:3][C:4]([N:6]([CH3:15])[N:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[NH:5].C(N(CC)CC)C.[C:23](Cl)(=[O:25])[CH3:24]>ClCCl>[CH3:2][S:3][C:4]([N:6]([CH3:15])[N:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[N:5][C:23](=[O:25])[CH3:24]

参加物

実験手順

Methyl-1-methyl-2-(phenylmethylene)hydrazinecarboximidothioate-hydroiodide* (4 g) and triethylamine (2.5 g) were dissolved in dichloromethane (50 ml). To this solution acetyl chloride (1.05 g) was added slowly maintaining temperature below 20° C. The mixture was stirred at room temperature in a dry nitrogen atmosphere for 1.5 h. The organic residues were washed with water (5×20 ml), dried over anhydrous sodium sulphate and the solvent removed in vacuo giving a yellow solid which upon trituration with ether gave the title compound (2.30 g) as an off-white solid of m.pt. 102°-104° C.