Methyl Thioglycolate → Methyl ((4-(4-chlorophenyl)-1-(4-hydroxyphenyl)-1-butyl)thio)acetate

HRID 2253752ノート

反応式

HRID 2253752 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)O)=[CH:4][CH:3]=1.[C:20]([O:24][CH3:25])(=[O:23])[CH2:21][SH:22]>C(Cl)Cl.[Zn+2].[I-].[I-]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([S:22][CH2:21][C:20]([O:24][CH3:25])=[O:23])[C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 16907Methyl ThioglycolateHCID 197458724-(4-(4-Chlorophenyl)-1-hydroxybutyl)phenol

生成物 1

HCID 54384776Methyl ((4-(4-chlorophenyl)-1-(4-hydroxyphenyl)-1-butyl)thio)acetate

試薬・触媒・溶媒 2

HCID 9883512zinc(II)iodide触媒HCID 6344Dichloromethane溶媒

実験手順

To a suspension of the alcohol (0.23 g) (Step VI) in CH2Cl2 (5 mL) and methyl thioglycolate (80 μL) was added ZnI2 (10 mg). The mixture was stirred 2 hrs, buffer (pH 7) was added. The mixture was extracted with ethyl acetate, which was dried and evaporated. Flash chromatography using 5% ethyl acetate in toluene afforded the title compound.

後処理

  1. additionbuffer (pH 7) was added
  2. extractionThe mixture was extracted with ethyl acetate, which
  3. customwas dried
  4. customevaporated

出典と根拠

ORDレコード
ord-d8633e2412724c49b74225f7a8783f4f
出典データセット
uspto-grants-1993_08
特許番号
US05232916

反応ノート

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