Acetic Acid → N-(4-Fluorobenzylidene)aniline
反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C1C=CC=CC=1.C(O)(=O)C>O>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1参加物
6
実験手順
To 4-fluorobenzaldehyde (24.8 g, 0.200 mol) and aniline (18.6 g, 0.200 mol) was added benzene (200 mL) and acetic acid (0.7 mL) and the mixture is heated under reflux until all the water (3.6 mL) was azeotropically removed. The solvent is evaporated and the residual oil upon cooling and stirring crystallized. The white mass was then recrystallize as needles (28 g, 70%): mp 39°-40° C. (PE) (lit.1 mp 40° C.).
後処理
- temperaturethe mixture is heated
- customwas azeotropically removed
- customThe solvent is evaporated
- temperaturethe residual oil upon cooling
- customcrystallized
- customThe white mass was then recrystallize as needles (28 g, 70%)
出典と根拠
- ORDレコード
- ord-a5a88fdc0f8f4d1dbd847707efe99421
- 出典データセット
- uspto-grants-1993_08
- 特許番号
- US05233046
反応ノート
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