Water → HCID 19743503、化合物

HRID 2254033ノート

反応式

HRID 2254033 の反応式
[K].[Cl:2][C:3]1[CH:19]=[CH:18][C:6]2[N:7]=[C:8]([O:10][C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=3)[O:9][C:5]=2[CH:4]=1.[C:20]([CH:22]([C:28]1[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][C:29]=1[Cl:35])[C:23](=[O:27])[CH:24](Cl)[CH3:25])#[N:21].O>CN(C)C=O>[C:20]([CH:22]([C:28]1[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][C:29]=1[Cl:35])[C:23](=[O:27])[CH:24]([O:17][C:14]1[CH:13]=[CH:12][C:11]([O:10][C:8]2[O:9][C:5]3[CH:4]=[C:3]([Cl:2])[CH:19]=[CH:18][C:6]=3[N:7]=2)=[CH:16][CH:15]=1)[CH3:25])#[N:21]

参加物

6

反応物 4

HCID 962WaterHCID 155475Phenol, 4-((6-chloro-2-benzoxazolyl)oxy)-HCID 5462222PotassiumHCID 197435991-Cyano-1-(2,4-dichlorophenyl)-3-chloro-2-butanone

生成物 1

HCID 19743503HCID 19743503、化合物収率 46.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

2.70 Grams of a potassium salt of 4-(6-chloro-2-benzoxazolyloxy)phenol and 2.48 g of 1-cyano-1-(2,4-dichlorophenyl)-3-chloro-2-butanone were refluxed in 50 ml of N,N-dimethylformamide under heat at 100° C. for 4 hours. The reaction mixture was added to water, and after the mixture was subjected to extraction with chloroform, the extract was concentrated. The residue was separated and purified by column chromatography to give 2.05 g of a compound No. 176 which was a light yellow solid (melting point 93°-94° C.). The yield was 46.9%. The compound No. 176 was analyzed, and the results are shown in Tables 1 to 23.

後処理

  1. extractionafter the mixture was subjected to extraction with chloroform
  2. concentrationthe extract was concentrated
  3. customThe residue was separated
  4. custompurified by column chromatography

出典と根拠

ORDレコード
ord-3c209366620e4fa698b926cccc96231f
出典データセット
uspto-grants-1993_08
特許番号
US05234894

反応ノート

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