Potassium Carbonate → 1-(4-Cyano-2-methoxybenzyl)-6-nitroindole

反応式

[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Br[CH2:14][C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][C:16]=1[O:23][CH3:24].C(=O)([O-])[O-].[K+].[K+]>>[C:19]([C:18]1[CH:21]=[CH:22][C:15]([CH2:14][N:10]2[C:11]3[C:7](=[CH:6][CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:12]=3)[CH:8]=[CH:9]2)=[C:16]([O:23][CH3:24])[CH:17]=1)#[N:20]

参加物

反応物 3

HCID 11430Potassium Carbonate

HCID 785026-Nitro-1H-indole

HCID 147529954-(Bromomethyl)-3-methoxybenzonitrile

生成物 1

HCID 147529961-(4-Cyano-2-methoxybenzyl)-6-nitroindole収率 78%

実験手順

6-Nitroindole as alkylated with 4-bromomethyl-3-methoxybenzonitrile in the presence of potassium carbonate using the general procedure described. in Ex 1(a) to give 1-(4-cyano-2-methoxybenzyl)-6-nitroindole (W) in 78% yield as a solid, m.p. 190.5°-191° C.

出典と根拠

ORDレコード: ord-3b153b387d5e476aba4c69e5e365bfb0
出典データセット: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05234942

反応ノート

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