Hydrochloric Acid → HCID 19744875、化合物

HRID 2254245ノート

反応式

HRID 2254245 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([C:11](=[O:22])[CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[C:5]([O:23][CH2:24][C:25]([O:27]C)=[O:26])[CH:4]=1.[OH-].[K+].Cl>CO>[C:25]([CH2:24][O:23][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[C:6]=1[C:11](=[O:22])[CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=1)([OH:27])=[O:26]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19744869HCID 19744869、化合物

生成物 1

HCID 19744875HCID 19744875、化合物収率 87.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Then, 6.05 g of 1-(4,6-dimethoxy-2-methoxycarbonylmethoxyphenyl)-3-(4-methoxyphenyl)-1-propanone was dissolved in 50 ml of methanol, and 30 ml of a 5% aqueous solution of potassium hydroxide was added to the solution and the mixture was stirred at room temperature for 30 minutes to effect reaction. After the reaction, the reaction mixture was made acidic by addition of dilute hydrochloric acid, extracted with diethyl ether and filtered, and the solvent was removed from the filtrate by distillation and the obtained residue was recrystallized from a mixed solvent of diethyl ether and n-hexane to obtain 5.0 g (yield=87.4%) of 1-(2-carboxymethoxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-propanone in the form of a colorless prism.

後処理

  1. customreaction
  2. customAfter the reaction
  3. extractionextracted with diethyl ether
  4. filtrationfiltered
  5. customthe solvent was removed from the filtrate by distillation
  6. customthe obtained residue was recrystallized from a mixed solvent of diethyl ether and n-hexane

出典と根拠

ORDレコード
ord-49474fc552a147d5b14ef1df2a7e3a01
出典データセット
uspto-grants-1993_08
特許番号
US05234951

反応ノート

読み込み中…