HCID 19744814、化合物 → 3-(1H-Imidazol-1-yl)benzenemethanol

HRID 2254450ノート

反応式

HRID 2254450 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:9]=[CH:10][CH:11]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(Cl)(Cl)Cl.CO>C(OCC)C>[OH:3][CH2:4][C:6]1[CH:7]=[C:8]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:9]=[CH:10][CH:11]=1

参加物

5

反応物 3

HCID 19744814HCID 19744814、化合物HCID 21226445Aluminium lithium hydrideHCID 21584188Chloroform methanol

生成物 1

HCID 197444983-(1H-Imidazol-1-yl)benzenemethanol収率 92%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

230 mg of 1-(3-ethoxycarbonylphenyl)imidazole see J. Am. Chem. Soc., 79, 4922 (1957)1 was dissolved in ml of ethyl ether, and 50 mg of lithium aluminium hydride was added. The mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into ice water. The organic layer was separated and dried over anhydrous magnesium sulfate. The desiccant was separated by filtration. The solvent was evaporated and then the residue was purified by silica gel column chromatography Wakogel C-200, 20 g; eluting solvent: chloroform/methanol=20/1) to give 160 mg (yield 92%) of the captioned compound as a colorless oil.

後処理

  1. additionwas added
  2. customThe organic layer was separated
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe desiccant was separated by filtration
  5. customThe solvent was evaporated
  6. customthe residue was purified by silica gel column chromatography Wakogel C-200, 20 g

出典と根拠

ORDレコード
ord-81e2dad3bd784cb0b040798920470948
出典データセット
uspto-grants-1993_08
特許番号
US05234946

反応ノート

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