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Thionyl Chloride → 3-[(4-Bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Aminothiophene-2-carboxamide | HCID 518993 | — |
| 反応物 | 4-Bromo-2,5-difluorobenzoic acid | HCID 822857 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-[(4-Bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide | HCID 57753049 | — |
反応手順
After stirring a mixture of 4-bromo-2,5-difluorobenzoic acid and thionyl chloride for one hour at 80° C., the solution was removed and an oily substance was obtained. A mixture of the obtained oily substance, 3-aminothiophene-2-carboxamide, N,N-diisopropylethylamine and THF was stirred for two hours under ice cooling to give 3-[(4-bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557112B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-ceaa1bcb15a74d6782e47e4c3384fc3c |
| 出典メモ | uspto-grants-2009_07 |