Sodium Methoxide → (2E,7R,11R)-1-Methoxy-3,7,11,15-tetramethyl-2-hexadecene

HRID 2254655ノート

反応式

HRID 2254655 の反応式
[CH2:1](Cl)/[CH:2]=[C:3](/[CH2:5][CH2:6][CH2:7][C@@H:8]([CH2:10][CH2:11][CH2:12][C@@H:13]([CH2:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH3:14])[CH3:9])\[CH3:4].[CH3:22][O-:23].[Na+]>CO.C(OCC)(=O)C>[CH2:1]([O:23][CH3:22])/[CH:2]=[C:3](/[CH2:5][CH2:6][CH2:7][C@@H:8]([CH2:10][CH2:11][CH2:12][C@@H:13]([CH2:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH3:14])[CH3:9])\[CH3:4]

参加物

5

反応物 2

HCID 10942334Sodium MethoxideHCID 11130851Phytyl chloride

生成物 1

HCID 6476636(2E,7R,11R)-1-Methoxy-3,7,11,15-tetramethyl-2-hexadecene収率 95.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
60 °C

実験手順

10.0 g of phytyl chloride was dropped into a solution of 2.0 g of sodium methoxide dissolved in 70 ml of methanol. The resulting mixture was stirred for 4 hours at 60° C. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue obtained was dissolved in 30 ml of ethyl acetate, and the resulting solution was washed with water. The solution was dried over anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure. The residue thus obtained was subjected to distillation (b.p.: 148°-150° C., 1.5 mmHg) to obtain 9.4 g (yield: 95%) of oily methyl phytyl ether.

後処理

  1. customAfter the completion of the reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customThe residue obtained
  4. washthe resulting solution was washed with water
  5. dry with materialThe solution was dried over anhydrous magnesium sulfate
  6. customthe solvent was removed by distillation under reduced pressure
  7. customThe residue thus obtained
  8. distillationwas subjected to distillation (b.p.: 148°-150° C., 1.5 mmHg)

出典と根拠

ORDレコード
ord-5bc8f7b74a8643cf87b0c24864c3fcbe
出典データセット
uspto-grants-1993_08
特許番号
US05236950

反応ノート

読み込み中…