Dimethylformamide → Fadrozole

HRID 22548

反応式

HRID 22548 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:17][N:18](C)C=O>O>[C:17]([C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1)#[N:18]

参加物

4

反応物 2

HCID 6228DimethylformamideHCID 140971965-(p-Bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

生成物 1

HCID 59693Fadrozole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 85 mg of 5-(p-bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 74 mg of cuprous cyanide in 1 ml of N,N-dimethylformamide is heated under nitrogen at 120° for 11 h. The reaction mixture is cooled, diluted with 10 ml of water and extracted with ethyl acetate. The organic extracts are dried over sodium sulfate and evaporated. The resulting oil is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.

後処理

  1. temperatureis heated under nitrogen at 120° for 11 h
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic extracts are dried over sodium sulfate
  5. customevaporated
  6. customThe resulting oil is chromatographed on silica gel with ethyl acetate

出典と根拠

ORDレコード
ord-00f7638125924cf68d1eb79ce35a532a
出典データセット
uspto-grants-1995_06
特許番号
US05428160

関連ノート

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