Dimethylformamide → Fadrozole
反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:17][N:18](C)C=O>O>[C:17]([C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1)#[N:18]参加物
4
実験手順
A mixture of 85 mg of 5-(p-bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 74 mg of cuprous cyanide in 1 ml of N,N-dimethylformamide is heated under nitrogen at 120° for 11 h. The reaction mixture is cooled, diluted with 10 ml of water and extracted with ethyl acetate. The organic extracts are dried over sodium sulfate and evaporated. The resulting oil is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.
後処理
- temperatureis heated under nitrogen at 120° for 11 h
- temperatureThe reaction mixture is cooled
- extractionextracted with ethyl acetate
- dry with materialThe organic extracts are dried over sodium sulfate
- customevaporated
- customThe resulting oil is chromatographed on silica gel with ethyl acetate
出典と根拠
- ORDレコード
- ord-00f7638125924cf68d1eb79ce35a532a
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05428160
反応ノート
読み込み中…