p-Fluoronitrobenzene → HCID 12874832、化合物

HRID 2255081ノート

反応式

HRID 2255081 の反応式
[CH3:1][N:2]([CH3:13])[CH2:3][CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[OH:6].F[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1>>[CH3:13][N:2]([CH3:1])[CH2:3][CH2:4][CH:5]([O:6][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

3

反応物 2

HCID 9590p-FluoronitrobenzeneHCID 1106653-(Dimethylamino)-1-phenylpropan-1-ol

生成物 1

HCID 12874832HCID 12874832、化合物収率 88.5%

実験手順

Following the procedure of Example 3, 17.9 g of 3-dimethylamino-1-phenyl-1-propanol and 14.1 g of 1-fluoro-4-nitrobenzene were reacted to provide 26.54 g of the subtitle intermediate as a red oil. Preparation of the oxalate salt of a small portion of the oil provided yellow crystals with a melting point of 155°-157° C. (with decomposition).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-96f7f12ce73e463cae938e5b26dcfd07
出典データセット
uspto-grants-1993_08
特許番号
US05238959

反応ノート

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