Sulfuric Acid → Fadrozole

HRID 22551

反応式

HRID 22551 の反応式
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1)=O.[NH:18]=[N+]=[N-].S(=O)(=O)(O)O>C1C=CC=CC=1>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:18]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 24530Hydrazoic acidHCID 140971985-(p-Formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

生成物 1

HCID 59693Fadrozole

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A solution of 2.01 g of 5-(p-formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 0.96 g of hydrazoic acid in 30 ml benzene is maintained by external cooling at room temperature, while 0.8 ml of concentrated sulfuric acid is added dropwise. The reaction mixture is stirred for 2 h and neutralized. The organic phase is separated, dried over sodium sulfate and evaporated to yield an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound.

後処理

  1. additionis added dropwise
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulfate
  4. customevaporated
  5. customto yield an oil which
  6. customis chromatographed on silica gel with ethyl acetate

出典と根拠

ORDレコード
ord-a545b507d80343d3b599544805a9709c
出典データセット
uspto-grants-1995_06
特許番号
US05428160

関連ノート

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