Sulfuric Acid → Fadrozole
反応式
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1)=O.[NH:18]=[N+]=[N-].S(=O)(=O)(O)O>C1C=CC=CC=1>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:18]参加物
5
実験手順
A solution of 2.01 g of 5-(p-formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 0.96 g of hydrazoic acid in 30 ml benzene is maintained by external cooling at room temperature, while 0.8 ml of concentrated sulfuric acid is added dropwise. The reaction mixture is stirred for 2 h and neutralized. The organic phase is separated, dried over sodium sulfate and evaporated to yield an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound.
後処理
- additionis added dropwise
- customThe organic phase is separated
- dry with materialdried over sodium sulfate
- customevaporated
- customto yield an oil which
- customis chromatographed on silica gel with ethyl acetate
出典と根拠
- ORDレコード
- ord-a545b507d80343d3b599544805a9709c
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05428160
反応ノート
読み込み中…