1,1-Dimethylethyl N-[2-[(4-chlorobenzoyl)amino]ethyl]carbamate → N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride
反応式
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[O:7])=[CH:4][CH:3]=1>C(O)=O>[ClH:1].[NH2:11][CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]1[CH:19]=[CH:20][C:2]([Cl:1])=[CH:3][CH:4]=1参加物
3
実験手順
A solution of 2.8 g of t-butyl [2-(4-chlorobenzamido)ethyl]carbamate in 50 ml of formic acid is left to stand at room temperature for 1.5 hours. The mixture is then concentrated to dryness, and the residue is dissolved in 50 ml of hydrochloric acid(l:l; volume/volume). The solution is concentrated, the residue is evaporated twice with ethanol/benzene and then recrystallized from ethanol. There are obtained 2.1 g of N-(2-aminoethyl)-4-chlorobenzamide hydrochloride which is identical with the product obtained in Example 1.
後処理
- concentrationThe mixture is then concentrated to dryness
- dissolutionthe residue is dissolved in 50 ml of hydrochloric acid(l:l; volume/volume)
- concentrationThe solution is concentrated
- customthe residue is evaporated twice with ethanol/benzene
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-efdf32f9ee6c4804ab65832f207c47f4
- 出典データセット
- uspto-grants-1993_08
- 特許番号
- US05238962
反応ノート
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