Carbon Tetrachloride → 4-(3-Chloropropyl)-2,6-dimethylmorpholine

反応式

O[CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH3:12])[CH2:6]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Cl)(Cl)(Cl)[Cl:33]>>[Cl:33][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH3:12])[CH2:6]1

参加物

反応物 3

HCID 5943Carbon Tetrachloride

HCID 11776Triphenylphosphine

HCID 224782944-(3-Hydroxypropyl)-2,6-dimethylmorpholine

生成物 1

HCID 197380174-(3-Chloropropyl)-2,6-dimethylmorpholine

実験手順

This intermediate (2.3 g.) was prepared using the procedure described in Example 4c except using 5.0 g. (28 mmoles) of 4-(3-hydroxypropyl)-2,6-dimethylmorpholine and 9.5 g. (30 mmoles) of triphenylphosphine in 50 ml. of carbon tetrachloride and was isolated as a colorless liquid.

後処理

customThis intermediate (2.3 g.) was prepared

出典と根拠

ORDレコード: ord-4bca85dbe3a2417f979c381cad910a58
出典データセット: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05240925

反応ノート

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