2-Chlorophenol → 8-Chloro-4-(2-chlorophenoxy)quinoline

HRID 2255429ノート

反応式

HRID 2255429 の反応式
Cl[C:2]1[C:11]2[C:6](=[C:7]([Cl:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[OH:20]>C(OCC)(=O)C>[Cl:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[CH:4][CH:3]=[C:2]2[O:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[Cl:13]

参加物

4

反応物 2

HCID 72452-ChlorophenolHCID 889734,8-Dichloroquinoline2 回

生成物 1

HCID 1641768-Chloro-4-(2-chlorophenoxy)quinoline

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
160 °C

実験手順

A mixture of 2.0 g of 4,8-dichloroquinoline and 2.6 g of 2-chlorophenol was heated to 160° C. and stirred. Progress of the reaction was monitored by TLC. When no 4,8-dichloroquinoline remained, the reaction mixture was diluted with ethyl acetate, and washed with base to remove most of the excess phenol. To remove phenol remaining after washing, the product was purified using HPLC. Fractions containing product were combined, and solvent was removed using reduced pressure. The oily product crystallized. Yield: 1.36 g (46%). M.P. 56°-58° C.

後処理

  1. washwashed with base
  2. customto remove most of the excess phenol
  3. customTo remove phenol remaining
  4. washafter washing
  5. customthe product was purified
  6. additionFractions containing product
  7. customsolvent was removed
  8. customThe oily product crystallized

出典と根拠

ORDレコード
ord-34f41e1e9ec14f71baae171abbcd6d20
出典データセット
uspto-grants-1993_08
特許番号
US05240940

反応ノート

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