関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-Benzyl-4-piperidone | HCID 19220 | — |
| 反応物 | 5-Bromo-2,3-dihydro-1,4-benzodioxine | HCID 18787268 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 1-Benzyl-4-hydroxy-4-(1,4-benzodioxan-5-yl)piperidine | HCID 19082002 | — |
反応手順
23.3 ml of a 1.6 M solution of butyllithium in hexane are added dropwise to a solution, previously cooled to -60° C., of 8 g of 5-bromo-1,4-benzodioxane in 400 ml of tetrahydrofuran. When the addition is complete, the mixture is stirred at -60° C. for 5 minutes and a solution of 8 g of 1-benzylpiperid-4-one in 100 ml of tetrahydrofuran is then added dropwise. The mixture is stirred for 2 hours at -40° C. and then for 2 hours at ambient temperature before hydrolyzing using 80 ml of water.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05240942 |
|---|
| 出典データセット | uspto-grants-1993_08 |
|---|
| ORD ID | ord-309e95fb141340dfbad569e95c56726f |
|---|
| 出典メモ | uspto-grants-1993_08 |
|---|
