Sulfuric Acid → 3,4-Dichloro-5-isothiazolecarboxylic acid amide

HRID 2255489ノート

反応式

HRID 2255489 の反応式
[C:1]([C:3]1[S:7][N:6]=[C:5]([Cl:8])[C:4]=1[Cl:9])#[N:2].S1C=CC=N1.S(=O)(=O)(O)[OH:16]>>[Cl:8][C:5]1[C:4]([Cl:9])=[C:3]([C:1]([NH2:2])=[O:16])[S:7][N:6]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 67515IsothiazoleHCID 19738264Dichloro-1,2-thiazole-5-carbonitrile

生成物 1

HCID 113330673,4-Dichloro-5-isothiazolecarboxylic acid amide

反応条件

温度
110 °C

実験手順

Concentrated sulfuric acid (10 ml) was added to 1.0 g of 5-cyano-3,4-dichloroisothiazole. When heated at 110° C. for 20 minutes, the isothiazole compound was dissolved completely. The reaction mixture was cooled under ice cooling, and precipitated crystals were collected by filtration. The crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water.

後処理

  1. temperatureThe reaction mixture was cooled under ice cooling
  2. customprecipitated crystals
  3. filtrationwere collected by filtration
  4. customThe crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water

出典と根拠

ORDレコード
ord-d7ac6bbb142a47bb9ad3c6bbee0a4550
出典データセット
uspto-grants-1993_08
特許番号
US05240951

反応ノート

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