Ammonia → 2-(4-Methylphenoxy)-2-(2-chlorophenyl)acetamide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([O:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)[C:9](OC)=[O:10].[NH3:21]>CO>[CH3:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:9]([NH2:21])=[O:10])=[CH:15][CH:16]=1参加物
4
実験手順
To a solution of 0.700 g (2.41 mmol) of methyl 2-(2-chlorophenyl)-2-(4-methylphenoxy)acetate (Example 4, Step B) in 10 mL of methanol, stirred at 0° C. (ice-bath) was added anhydrous NH3 for 45 minutes. The reaction mixture was warmed to room temperature and stirred overnight. The reaction mixture was then concentrated in vacuo and afforded 0.658 g (99%) of title compound.
後処理
- concentrationThe reaction mixture was then concentrated in vacuo
出典と根拠
- ORDレコード
- ord-8a0c087c34db4429bac9b810426c303e
- 出典データセット
- uspto-grants-1993_08
- 特許番号
- US05240938
反応ノート
読み込み中…