Hydrochloric Acid → 5-(4-Methyl-thiazol-2-yl)-2,3-dihydro-1H-isoindole

反応式

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[S:18][CH:19]=[C:20]([CH3:22])[N:21]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[CH3:22][C:20]1[N:21]=[C:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[S:18][CH:19]=1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 577537115-(4-Methyl-thiazol-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

生成物 1

HCID 577535025-(4-Methyl-thiazol-2-yl)-2,3-dihydro-1H-isoindole

実験手順

Prepared in analogy to Example A3(e) from 5-(4-Methyl-thiazol-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and using trifluoacetic acid instead of hydrochloride acid. Brown solid. MS (m/e): 217.1 ([M+H]+, 100%)

出典と根拠

ORDレコード: ord-4faf4fcb9369433fb726abc2d9924fb5
出典データセット: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07557114B2

反応ノート

読み込み中…