Hydrochloric Acid → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 2255705ノート

反応式

HRID 2255705 の反応式
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2.Cl.C(=O)([O-])[O-].[K+].[K+]>O>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 19100959HCID 19100959、化合物

生成物 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.01octane-7-carboxylate are heated under reflux overnight with 30 ml of concentrated hydrochloric acid. The mixture ic concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate, extracted five times with 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. extractionextracted five times with 50 ml of chloroform each time
  2. dry with materialdried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-830de90d22b94c4091e4e4af99ec72f3
出典データセット
uspto-grants-1993_08
特許番号
US05241076

反応ノート

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