5-(p-Aminophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine → Fadrozole

HRID 22558

反応式

HRID 22558 の反応式
N[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.N([O-])=O.[Na+].[Cu][C:22]#[N:23]>Cl.O>[C:22]([C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1)#[N:23]

参加物

6

反応物 3

HCID 152947205-(p-Aminophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridineHCID 23668193Sodium NitriteHCID 178418546HCID 178418546、化合物

生成物 1

HCID 59693Fadrozole

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒3 回

実験手順

A solution of 2.13 g of 5-(p-aminophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine in 4 ml of concentrated hydrochloric acid and 10 ml of water is cooled in an ice-bath and a solution of 0.78 g of sodium nitrite in 2 ml of water is added slowly. The solution is added via dropping funnel to an ice cooled solution of 3.0 g of copper(I) cyanide in 10 ml of water, keeping the temperature between 30°-40°. The reaction mixture is heated on a steam bath for 1 h, cooled and brought to pH 9. The organic extracts are dried over sodium sulfate and evaporated and the residue is chromatographed on silica gel with ethyl acetate to yield the title compound.

後処理

  1. additionThe solution is added
  2. custombetween 30°-40°
  3. temperatureThe reaction mixture is heated on a steam bath for 1 h
  4. temperaturecooled
  5. dry with materialThe organic extracts are dried over sodium sulfate
  6. customevaporated
  7. customthe residue is chromatographed on silica gel with ethyl acetate

出典と根拠

ORDレコード
ord-14e5b909f4a74155a7d9cebed6739509
出典データセット
uspto-grants-1995_06
特許番号
US05428160

関連ノート

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