5-(p-Hydroxymethylphenyl)imidazo[1,5-a]pyridine → 5-(p-Formylphenyl)-imidazo[1,5-a]pyridine

HRID 22560ノート

反応式

HRID 22560 の反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH:12]=[CH:11][CH:10]=2)=[CH:7][CH:8]=1)=[O:1]

参加物

4

反応物 1

HCID 136494325-(p-Hydroxymethylphenyl)imidazo[1,5-a]pyridine

生成物 1

HCID 136494335-(p-Formylphenyl)-imidazo[1,5-a]pyridine

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒2 回HCID 6344Dichloromethane溶媒

実験手順

A solution of 5-(p-hydroxymethylphenyl)imidazo[1,5-a]pyridine (0.52 g) in 10 ml of methylene chloride is refluxed with 5.2 g of activated manganese dioxide for 24 h. An additional 5.2 g of manganese dioxide is added and the reaction mixture is refluxed an additional 6 h, filtered, and the solvent is evaporated to yield 5-(p-formylphenyl)-imidazo[1,5-a]pyridine, m.p. 144°-146°.

後処理

  1. temperaturethe reaction mixture is refluxed an additional 6 h
  2. filtrationfiltered
  3. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-741edcda20ec4dd68396b440300ebbef
出典データセット
uspto-grants-1995_06
特許番号
US05428160

反応ノート

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