Acetyl chloride → 4-(1,3-Dioxaindan-5-yl)oxane-2,6-dione
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([CH2:15][C:16]([OH:18])=[O:17])[CH2:11][C:12]([OH:14])=O)=[CH:9][C:4]=2[O:3][CH2:2]1.C(Cl)(=O)C>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]3[CH2:11][C:12](=[O:14])[O:18][C:16](=[O:17])[CH2:15]3)=[CH:9][C:4]=2[O:3][CH2:2]1参加物
3
実験手順
3-(1,3-benzodioxol-5-yl)glutaric acid (3.2 g) was treated with acetyl chloride (15 mL) and the resulting mixture heated at reflux for 5 hours. The cooled reaction mixture was then azeotroped with toluene (2×100 mL) and concentrated under reduced pressure. The residue was slurried with diethyl ether and filtered to afford the title compound (2.91 g).
後処理
- temperaturethe resulting mixture heated
- temperatureat reflux for 5 hours
- customThe cooled reaction mixture
- customwas then azeotroped with toluene (2×100 mL)
- concentrationconcentrated under reduced pressure
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-8e4d43cfa15241d7b249ba2e450e223c
- 出典データセット
- uspto-grants-1997_08
- 特許番号
- US05654316
反応ノート
読み込み中…