N-Methylaniline → HCID 70196436、化合物
反応式
[C:1]1([CH:7]2[CH2:13][C:12](=[O:14])[O:11][C:9](=[O:10])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CN[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH2:23]([N:25](CC)CC)C>C(Cl)Cl>[C:17]1([CH2:23][NH:25][C:12](=[O:14])[CH2:13][CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][C:9]([OH:11])=[O:10])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
3-Phenylglutaric anhydride (8.0 g) in CH2Cl2 (100 mL) at 0° C. was treated sequentially with N-methylaniline (5.63 g), triethylamine (5.32 g) and N,N-dimethylaminopyridine (1.0 g). The mixture was stirred at 0° C. for two hours then allowed to warm to room temperature and stirred for 12 hours. The reaction mixture was washed with 1N HCl (2×50 mL) and water (100 mL). The organic layers were dried over MgSO4, filtered and concentrated to afford the title compound (11.5 g).