1,2-Dibromoethane → HCID 22905874、化合物

HRID 2257251ノート

反応式

HRID 2257251 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:3]=1[OH:13].[Br:14][CH2:15][CH2:16]Br.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([C:9]([CH3:10])([CH3:12])[CH3:11])[C:3]=1[O:13][CH2:16][CH2:15][Br:14]

参加物

5

反応物 3

HCID 78391,2-DibromoethaneHCID 11430Potassium CarbonateHCID 719757AKOS BBS-00008108

生成物 1

HCID 22905874HCID 22905874、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 2,4-dibromo-6-tert-butylphenol (5.00 g, 16.2 mmol) in acetone (70 mL) is added 1,2-dibromoethane (2.80 mL, 32.5 mmol) and K2CO3 (6.70 g, 48.7 mmol). The mixture is heated at reflux for 14 h, and then is filtered and evaporated. The residue is purified by chromatography over SiO2 eluting with hexanes. The resulting oil is distilled to give 1,5-dibromo-(2-bromoethoxy)-3-tert-butylbenzene as a pale yellow oil.

後処理

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 14 h
  3. filtrationis filtered
  4. customevaporated
  5. customThe residue is purified by chromatography over SiO2 eluting with hexanes
  6. distillationThe resulting oil is distilled

出典と根拠

ORDレコード
ord-0d5c9bdccbd14d19ba2bc61a53154bc0
出典データセット
uspto-grants-1997_08
特許番号
US05656661

反応ノート

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