5-(2-(2-(Nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)-1-bromopentane → 5-Hexyloxy-2-[4-(5-(2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)pentyloxy)phenyl]pyrimidine
反応式
[CH2:1]([O:7][C:8]1[CH:9]=[N:10][C:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)=[N:12][CH:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[F:21][C:22]([F:52])([C:48]([F:51])([F:50])[F:49])[C:23]([F:47])([F:46])[C:24]([F:45])([F:44])[O:25][C:26]([F:43])([F:42])[C:27]([F:41])([F:40])[O:28][C:29]([F:39])([F:38])[CH2:30][O:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]Br>>[CH2:1]([O:7][C:8]1[CH:13]=[N:12][C:11]([C:14]2[CH:15]=[CH:16][C:17]([O:20][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][O:31][CH2:30][C:29]([O:28][C:27]([F:40])([F:41])[C:26]([F:42])([F:43])[O:25][C:24]([F:44])([F:45])[C:23]([F:46])([F:47])[C:22]([F:21])([F:52])[C:48]([F:51])([F:50])[F:49])([F:39])[F:38])=[CH:18][CH:19]=2)=[N:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]参加物
3
実験手順
The title compound was prepared essentially as in Example 1 by combining 5-hexyloxy-2-(4-hydroxyphenyl)pyrimidine (8.0 g, 29.4 mmol) and 5-(2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)-1-bromopentane (18.6 g, 32 mmol, Example 2). The resulting crude product was isolated and further purified essentially as described in Example 1 (b.p. 210°-25° C. at 0.3 torr).