Ethyl Acetate → HCID 86594851、化合物

HRID 225774

反応式

HRID 225774 の反応式
[C:1]([NH2:11])(=[O:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Br[CH:13]([CH3:21])[C:14](=O)[CH2:15][C:16]([O:18][CH3:19])=[O:17].C(OC(=O)C)C>CN(C)C=O>[CH3:21][C:13]1[O:10][C:1]([CH:2]=[CH:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[N:11][C:14]=1[CH2:15][C:16]([O:18][CH3:19])=[O:17]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 121352-Propenamide, 3-phenyl-HCID 9815681Methyl 4-bromo-3-oxopentanoate

生成物 1

HCID 86594851HCID 86594851、化合物収率 11.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

Cinnamamide (0.5 g) and methyl 4-bromo-3-oxopentanoate (0.71 g) were dissolved in N,N-dimethylformamide (2.5 ml) and the mixture was stirred 100° C. for 15 h. Ethylacetate (50 ml) was added, and the mixture was washed with water (100 ml) and then with saturated brine (100 ml), and dried (Na2SO4). Ethyl acetate was evaporated under reduced pressure and the obtained residue was purified by column chromatography to give the title compound (0.1 g).

後処理

  1. washthe mixture was washed with water (100 ml)
  2. dry with materialwith saturated brine (100 ml), and dried (Na2SO4)
  3. customEthyl acetate was evaporated under reduced pressure
  4. customthe obtained residue was purified by column chromatography

出典と根拠

ORDレコード
ord-c173fd40267040489bc68ac8304425c8
出典データセット
uspto-grants-2009_07
特許番号
US07557123B2

関連ノート

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