2-Aminothiazole → Thiourea, N-ethyl-N'-2-thiazolyl-
反応式
[CH2:1]([N:3]=[C:4]=[S:5])[CH3:2].[NH2:6][C:7]1[S:8][CH:9]=[CH:10][N:11]=1.C(OCC)(=O)C>CN(C)C=O>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[S:8][CH:9]=[CH:10][N:11]=1)=[S:5])[CH3:2]参加物
5
実験手順
A solution of ethyl isothiocyanate (1.74 g, 20 mmol) and 2-aminothiazole (2.0 g, 20 mmol) in N,N-dimethylformamide (50 mL) was heated at 100° C. for 23 h. The reaction was cooled to room temperature, poured into ethyl acetate, washed with water, 1N aqueous HCl, water, saturated sodium bicarbonate, and brine. The organic layer was concentrated and the residue recrystallized twice from ethyl acetate to provide 0.48 g (13%) of the title product:
後処理
- washwashed with water, 1N aqueous HCl, water, saturated sodium bicarbonate, and brine
- concentrationThe organic layer was concentrated
- customthe residue recrystallized twice from ethyl acetate
出典と根拠
- ORDレコード
- ord-4fd4789e1ea449ba8f4f1e20a0781ce4
- 出典データセット
- uspto-grants-1997_08
- 特許番号
- US05658907
反応ノート
読み込み中…