2,4-Dimethoxyphenyl isocyanate → Ethyl 2-(4-{2-[3-(2,4-dimethoxyphenyl)-1-heptylureido]ethyl}phenoxy)-2-methylpropionate

HRID 2258022ノート

反応式

HRID 2258022 の反応式
[CH2:1]([NH:8][CH2:9][CH2:10][C:11]1[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=1[N:36]=[C:37]=[O:38]>C(Cl)Cl>[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=1[NH:36][C:37](=[O:38])[N:8]([CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:24][CH:25]=1)[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

4

反応物 2

HCID 6016372,4-Dimethoxyphenyl isocyanateHCID 23192930Ethyl 2-[4-(heptylaminoethyl)phenoxy]-2-methylpropionate

生成物 1

HCID 22924175Ethyl 2-(4-{2-[3-(2,4-dimethoxyphenyl)-1-heptylureido]ethyl}phenoxy)-2-methylpropionate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The product from step (d) (2.1 g) and 2,4-dimethoxyphenylisocyanate (1.1 g, Aldrich) were dissolved in CH2Cl2 (50 ml). The resulting solution was stirred at room temperature for 17 hours and then evaporated in vacuo. The residue was flash chromatographed through a silica column using hexanes/CH2C1 /EtOAc (50:25:25) as eluant to give the desired product as a very light brown oil (2.0 g).

後処理

  1. customevaporated in vacuo
  2. customchromatographed through a silica column

出典と根拠

ORDレコード
ord-c033c022daa94816a823a761b469f875
出典データセット
uspto-grants-1997_08
特許番号
US05658944

反応ノート

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