Aniline → N-(2-Ethylhexyl)aniline

HRID 2258366ノート

反応式

HRID 2258366 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8]([CH:10]([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:11]Br)[CH3:9].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:8]([CH:10]([CH2:13][CH2:14][CH2:15][CH3:16])[CH2:11][NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:9]

参加物

5

反応物 3

HCID 6115AnilineHCID 11430Potassium CarbonateHCID 868042-Ethylhexyl bromide

生成物 1

HCID 61484N-(2-Ethylhexyl)aniline収率 43%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
75 °C

実験手順

A mixture of aniline (18.6 parts), 2-ethylhexyl bromide (42.4 parts), anhydrous potassium carbonate (30.3 parts) and dry N,N-dimethylformamide (100 parts) was stirred at 75° C. for 24 hours. The cooled mixture was filtered, diluted with dichloromethane and washed with 2N-hydrochloric acid (100 parts). The organic phase was evaported to leave oil which was triturated with petroleum ether and water to give N-(2-ethylhexyl)aniline (18 parts, 43%).

後処理

  1. filtrationThe cooled mixture was filtered
  2. additiondiluted with dichloromethane
  3. washwashed with 2N-hydrochloric acid (100 parts)
  4. customto leave oil which
  5. customwas triturated with petroleum ether and water

出典と根拠

ORDレコード
ord-d94dd24deb4248fabd62c5794952b6d3
出典データセット
uspto-grants-1997_08
特許番号
US05660598

反応ノート

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