Diethylenetriamine → 3-[6-[[[2-[(2-Aminoethyl)amino]ethyl]amino]acetyl amino]-1-oxohexyl]amino-alpha-ethyl-2,4,6-triiodobenzenepropanoic acid

HRID 2258390

反応式

HRID 2258390 の反応式
[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH2:7].Cl[CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH:20][C:21]1[C:22]([I:36])=[C:23]([CH2:29][CH:30]([CH2:34][CH3:35])[C:31]([OH:33])=[O:32])[C:24]([I:28])=[CH:25][C:26]=1[I:27])=[O:19])=[O:11]>>[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH:20][C:21]1[C:22]([I:36])=[C:23]([CH2:29][CH:30]([CH2:34][CH3:35])[C:31]([OH:33])=[O:32])[C:24]([I:28])=[CH:25][C:26]=1[I:27])=[O:19])=[O:11]

参加物

3

反応物 2

HCID 8111DiethylenetriamineHCID 229214013-[[6-[(Chloroacetyl)amino]-1-oxohexyl]amino]-alpha-ethyl-2,4,6-triiodobenzenepropanoic acid

生成物 1

HCID 229213963-[6-[[[2-[(2-Aminoethyl)amino]ethyl]amino]acetyl amino]-1-oxohexyl]amino-alpha-ethyl-2,4,6-triiodobenzenepropanoic acid収率 48%

実験手順

According to the procedure described in Example 1, 123 g of diethylenetriamine (0.16 mol) are reacted with 121.7 g of compound (A) 3-[[6-[(chloroacetyl)amino]-1-oxohexyl]amino]-α-ethyl-2,4,6-triiodobenzene propanoic acid. 64 g of 3-[6-[[[2-[(2-aminoethyl)amino]ethyl]amino]acetyl amino]-1-oxohexyl]amino-α-ethyl-2,4,6-triiodobenzenepropanoic acid (0.077 mol) are obtained.

出典と根拠

ORDレコード
ord-ea061e85110a46328f899d27dccab96f
出典データセット
uspto-grants-1997_08
特許番号
US05660814

関連ノート

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