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Benzoyl Peroxide → 2-(Bromomethyl)-7-chloroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl Peroxide | HCID 7187 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 7-Chloro-2-methylquinoline | HCID 138395 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 2-(Bromomethyl)-7-chloroquinoline | HCID 10244160 | — |
反応手順
A stirred suspension of N-bromosuccinimide (9.0 g), 7-chloroquinaldine (9.0 g), dibenzoylperoxide (0.5 g ) in CCl4 (200 ml) at 90° was illuminated with a 225W sunlamp for 6 hours. The suspension was cooled and passed through a plug of silica gel. The plug of silica gel was washed with 30% ether in hexane and the filtrate was evaporated. Flash chromatography of the residue using 30% ether in hexane afforded the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05428171 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-fbd00b5413db49c0a6a962721018cef8 |
| 出典メモ | uspto-grants-1995_06 |