Phenol → Methyl 3-phenoxy-3-phenyl-2-hydroxybutyrate

HRID 2258457ノート

反応式

HRID 2258457 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:8]1([C:14]2([CH3:21])[O:20][CH:15]2[C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[O:7]([C:14]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([CH3:21])[CH:15]([OH:20])[C:16]([O:18][CH3:19])=[O:17])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 996PhenolHCID 228011Methyl 3-methyl-3-phenyloxirane-2-carboxylate

生成物 1

HCID 15766824Methyl 3-phenoxy-3-phenyl-2-hydroxybutyrate

実験手順

28.2 g (0.3 mol) of phenol and 19.2 g (0.1 mol) of methyl 3-phenyl-2,3-epoxybutyrate are heated together for 6 hours at 100° C. After the excess phenol has been distilled off under greatly reduced pressure and the residue has been purified by chromatography over silica gel using a hexane/ethyl acetate mixture, 17.9 g of a slightly yellow oil are obtained.

後処理

  1. distillationAfter the excess phenol has been distilled off under greatly reduced pressure
  2. customthe residue has been purified by chromatography over silica gel using a hexane/ethyl acetate mixture, 17.9 g of a slightly yellow oil
  3. customare obtained

出典と根拠

ORDレコード
ord-d170f804c292465eab05bfc8ecc73c93
出典データセット
uspto-grants-1997_08
特許番号
US05661106

反応ノート

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