化工社化工社 化学情報印刷レポート · 研究参考用
1,8-Naphthyridine → 1,2,3,4-Tetrahydro-1,8-naphthyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,8-Naphthyridine | HCID 136069 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1,2,3,4-Tetrahydro-1,8-naphthyridine | HCID 13047367 | 100.9% |
反応手順
1,8-Naphthyridine (1.0 g, 7.68 mmole) was hydrogenated (50 psi) with 10% Pd/C (100 mg) in absolute ethanol (40 mL) for 18 hr. The mixture was filtered through a pad of Celite® and the filtrate was concentrated to give the title compound (1.04 g) which was sufficiently pure for use in the next step: MS (ES) m/e 135 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557125B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-82a58752556d48e6a1823e5f14201893 |
| 出典メモ | uspto-grants-2009_07 |