Homoveratrylamine → N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-hydroxy-2-phenylacetamide

HRID 2258462

反応式

HRID 2258462 の反応式
[C:1]([O:11]C)(=O)[CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH2:23][CH2:24][NH2:25])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH2:23][CH2:24][NH:25][C:1](=[O:11])[CH:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[OH:3])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]

参加物

3

反応物 2

HCID 8421HomoveratrylamineHCID 78066(+-)-Methyl mandelate

生成物 1

HCID 596397N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-hydroxy-2-phenylacetamide

実験手順

33.2 g (0.2 Mol) of methyl mandelate and 72 g (0.4 Mol) of 2-(3,4-dimethoxyphenyl)-ethylamine are heated to 160°-165° C. under an N2 atmosphere with stirring, for 5 hours using a descending condenser (to remove the methanol released). The cooled residue-is dissolved in 300 ml of ethyl acetate, washed twice with 100 ml of 2N HCl, once with saturated NaHCO3 solution and saturated NaCl solution, dried over MgSO4 and distilled off from the solvent.

後処理

  1. customto remove the methanol
  2. dissolutionThe cooled residue-is dissolved in 300 ml of ethyl acetate
  3. washwashed twice with 100 ml of 2N HCl, once with saturated NaHCO3 solution and saturated NaCl solution
  4. dry with materialdried over MgSO4
  5. distillationdistilled off from the solvent

出典と根拠

ORDレコード
ord-a1636792ae2849169787cfa5b6cdd0ca
出典データセット
uspto-grants-1997_08
特許番号
US05661157

関連ノート

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