Urea → 1-Phenyl-3-propylurea

HRID 2258478ノート

反応式

HRID 2258478 の反応式
C1(N=C=O)C=CC=CC=1.C(N)CC.NC(N)=O.C(CC(O)=O)#N.N([O-])=O.[Na+].N[C:29]1[N:34]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:33](=[O:41])[N:32](CCC)[C:31](=O)[CH:30]=1.[H][H].NC1C(=O)N(CCC)C(=O)N(C2C=CC=CC=2)C=1N>>[CH2:31]([NH:32][C:33]([NH:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:41])[CH2:30][CH3:29]

参加物

9

反応物 8

HCID 1176UreaHCID 7672Phenyl isocyanateHCID 7852PropylamineHCID 9740Cyanoacetic acidHCID 158590685,6-Diamino-1-phenyl-3-propylpyrimidine-2,4(1H,3H)-dioneHCID 229220916-Amino-1-phenyl-3-propylpyrimidine-2,4(1H,3H)-dioneHCID 23668193Sodium NitriteHCID 178418361HCID 178418361、化合物

生成物 1

HCID 36041381-Phenyl-3-propylurea

実験手順

N-Propyl-N'-phenylurea was prepared preliminarily from phenyl isocyanate and propylamine by the same procedure as in Reference Example 1. The urea compound as the starting material was reacted with cyanoacetic acid to form a uracil ring. Using sodium nitrite a nitroso group was introduced into the 5-position of the uracil ring in the obtained 6-amino-1-phenyl-3-propyluracil and then reduced with hydrogen gas to prepare 5,6-diamino-1-phenyl-3-propyluracil.

後処理

  1. customto form a uracil ring

出典と根拠

ORDレコード
ord-63a3d71f38ba47f682fe485b3b780e32
出典データセット
uspto-grants-1997_08
特許番号
US05661153

反応ノート

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