Ammonium Hydroxide → 5-(4-Quinolinylmethylene)-2-thioxo-4-thiazolidinone

HRID 2258497ノート

反応式

HRID 2258497 の反応式
[S:1]1[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[OH-].[NH4+].[Cl-].[NH4+].[N:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH:22]=O)=[CH:14][CH:13]=1>C(O)C>[N:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH:22]=[C:7]2[S:1][C:2](=[S:3])[NH:4][C:5]2=[O:6])=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 14923Ammonium HydroxideHCID 25517Ammonium ChlorideHCID 780724-QuinolinecarboxaldehydeHCID 1201546Rhodanine

生成物 1

HCID 43702165-(4-Quinolinylmethylene)-2-thioxo-4-thiazolidinone収率 89%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
5 °C

実験手順

Rhodanine (2.2 g; 16.5 mmol), 1.3 ml of concentrated ammonium hydroxide and 1 g of ammonium chloride in 20 ml of ethanol were heated on a steam bath for 15 minutes. 4-Quinoline carboxaldehyde (2.6 g; 16.5 mmol) was added and the resulting mixture was heated on the steam bath for another hour. Upon cooling to 5° C. a precipitate formed. This precipitate was recovered by filtration and then washed with water to provide 4 g of title compound, m.p. 325°-328° C.

後処理

  1. temperaturethe resulting mixture was heated on the steam bath for another hour
  2. customformed
  3. filtrationThis precipitate was recovered by filtration
  4. washwashed with water

出典と根拠

ORDレコード
ord-5b56b6900c764ecdacbc3dcc1d85a4fc
出典データセット
uspto-grants-1997_08
特許番号
US05661168

反応ノート

読み込み中…