Hydrochloric Acid → HCID 22922296、化合物
反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([CH2:14][S:15]([CH2:18][C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=2)(=[O:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:39]>C(OCC)C>[ClH:39].[C:33]1([C:11]2([CH2:14][S:15]([CH2:18][C:19]3[CH:20]=[C:21]([C:29]([F:30])([F:31])[F:32])[CH:22]=[C:23]([C:25]([F:27])([F:28])[F:26])[CH:24]=3)(=[O:16])=[O:17])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1参加物
4
実験手順
1t-Butoxycarbonyl-4-phenyl-4-[3,5-bis(trifluoromethyl) benzylsulphonyl methyl]piperidine was dissolved in diethyl ether (5 ml) and ethereal HCl (5 ml) was added. The solution was left standing for 16 h, solvent was removed and residue was recrystallised from isopropyl alcohol/isopropyl ether giving 4-phenyl-4-[3,5-bis(trifluoromethyl)benzylsulphonylmethyl]piperidine hydrochloride (196 mg) as a white solid, m.p. 249° C. (dec), m/z (CI+) 466 (M+ +1). Found: C, 49.90; H, 4.36; N, 2.89. C21H21NO2SF6. HCl requires C, 50.25; H, 4.42; N, 2.79.