Hydrochloric Acid → Isopropyl L-methionate hydrochloride
反応式
[ClH:1].[CH:2]([O:5][C:6](=[O:20])[C@H:7]([CH2:16][CH2:17][S:18][CH3:19])[NH:8]C(OC(C)(C)C)=O)([CH3:4])[CH3:3]>CCOC(C)=O>[ClH:1].[CH:2]([O:5][C:6](=[O:20])[C@H:7]([CH2:16][CH2:17][S:18][CH3:19])[NH2:8])([CH3:4])[CH3:3]参加物
4
反応条件
- 温度
- -20 °C
実験手順
HCl gas was bubbled into a solution of N-(t-Butoxycarbonyl methionine isopropyl ester (20.5 g, 0.07 mol) in EtOAc (200 mL) with stirring and cooling to -20° C. for 10 min. The flask was stoppered and stirred at -20° C. for 1 h, argon was bubbled into the solution to remove excess HCl, then the solution was concentrated to dryness to give a white solid which was used without further purification.
後処理
- stirringstirred at -20° C. for 1 h
- customargon was bubbled into the solution
- customto remove excess HCl
- concentrationthe solution was concentrated to dryness
- customto give a white solid which
- customwas used without further purification
出典と根拠
- ORDレコード
- ord-5fe07a1a10214438b6c7a02e8393eb8e
- 出典データセット
- uspto-grants-1997_08
- 特許番号
- US05661161
反応ノート
読み込み中…