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Methanol → [(1,2-dimethyl-1H-indol-3-yl)methyl](methyl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 1,2-Dimethyl-1H-indole-3-carboxaldehyde | HCID 599084 | — |
| 生成物 | [(1,2-dimethyl-1H-indol-3-yl)methyl](methyl)amine | HCID 10877907 | — |
反応手順
To 1,2-dimethylindole-3-carboxaldehyde (11.50 g, 66.4 mmole) was added a solution of 2 M methylamine in methanol (100 mL, 200 mmole). The reaction was stirred for 4 h at RT then was concentrated to dryness to afford the crude title compound: 1H NMR (400 Hz, CDCl3) δ 8.55 (d, J=1.4 Hz, 1 H), 8.16 (d, J=7.5 Hz, 1 H), 7.42 (d, J=7.8 Hz, 1 H), 7.15 (t, 1 H), 7.07 (t, 1 H), 3.68 (s, 3 H), 3.41 (s, 3 H), 2.55 (s, 3 H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557125B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-c719e35e7d5248289ebf3230e4c3671f |
| 出典メモ | uspto-grants-2009_07 |