Hydrochloric Acid → 4-Fluoro-cinnamyl chloride
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[CH:9]=[CH2:10])=[CH:4][CH:3]=1.[ClH:12]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][CH2:10][Cl:12])=[CH:4][CH:3]=1参加物
4
実験手順
273.6 g (1.798 mol) of 1-(4-fluorophenyl)allyl alcohol were dissolved with stirring in 2,000 ml of methylene chloride. Subsequently, 101.0 g (2,770 mol) of hydrogen chloride were passed in over the course of 3 h, during which the temperature rose to 37° C. The mixture was then stirred for 1 h. After washing with 600 ml of ice-cold water and a mixture of 150 ml of saturated brine and 150 ml of water, the organic phase was dried over sodium sulfate and concentrated. 294.6 g (98%) of a brown oil were obtained.
後処理
- customwere passed in over the course of 3 h, during which
- customrose to 37° C
- washAfter washing with 600 ml of ice-cold water
- additiona mixture of 150 ml of saturated brine and 150 ml of water
- dry with materialthe organic phase was dried over sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-9c2abfae17fa4ef4a5431eb346963d08
- 出典データセット
- uspto-grants-1995_12
- 特許番号
- US05473080
反応ノート
読み込み中…