Hydrochloric Acid → HCID 18398665、化合物
反応式
Cl.[S:2]1[C:10]2[C:5](=[N:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[CH3:14]O>>[S:2]1[C:10]2[C:5](=[N:6][C:7]([C:11]([O:13][CH3:14])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1参加物
4
実験手順
To a solution of HCl (10%) in MeOH (10 mL) was added thieno[3,2-b]pyridine-5-carboxylic acid (1.0 g, 5.6 mmol, from Step 2, Example 1) and the mixture heated to reflux for 2 hr. After cooling to r.t., half the solvent was removed by evaporation and the remainder was partitioned between EtOAc and H2O. Solid NaHCO3 was added until the system remained basic. Separation, drying, and evaporation of the organic layer afforded 0.75 g (70%) of methyl thieno[3,2-b]pyridine-5-carboxylate.
後処理
- temperaturethe mixture heated
- temperatureto reflux for 2 hr
- customhalf the solvent was removed by evaporation
- customthe remainder was partitioned between EtOAc and H2O
- additionSolid NaHCO3 was added until the system
- customSeparation
- customdrying
- customevaporation of the organic layer
出典と根拠
- ORDレコード
- ord-dd3464fd6aef4c03888ce3d35671013e
- 出典データセット
- uspto-grants-1995_12
- 特許番号
- US05472964
反応ノート
読み込み中…