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Hydrochloric Acid → Indenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Cerium(III) chloride | HCID 24636 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 1H-inden-1-one | HCID 11815384 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Indenol | HCID 316919 | 99% |
反応手順
The indenone from Example 109 (0.5 g) is reduced with NaBH4 (0.05 g) and cerium chloride (0.5 g) in methanol (20 ml). The reaction in ended after 10 minutes and the reaction mixture is poured into water. The pH is taken to 5 by means of dilute HCl and the mixture is extracted with ethyl acetate. It is washed with water and the solvent is evaporated. Indenol (0.49 g; m.p. 134° C.) is obtained (yield: 99%; compound no. 110).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05475132 |
| 出典データセット | uspto-grants-1995_12 |
| ORD ID | ord-8715c1e83d4b4fa1bfc24d12c01a77fc |
| 出典メモ | uspto-grants-1995_12 |