Hydrochloric Acid → Indenol

HRID 2260021

反応式

HRID 2260021 の反応式
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[BH4-].[Na+].[Cl-].[Ce+3].[Cl-].[Cl-].Cl>CO.O>[CH:1]1([OH:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 24636Cerium(III) chlorideHCID 4311764Sodium borohydrideHCID 118153841H-inden-1-one

生成物 1

HCID 316919Indenol収率 99%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

The indenone from Example 109 (0.5 g) is reduced with NaBH4 (0.05 g) and cerium chloride (0.5 g) in methanol (20 ml). The reaction in ended after 10 minutes and the reaction mixture is poured into water. The pH is taken to 5 by means of dilute HCl and the mixture is extracted with ethyl acetate. It is washed with water and the solvent is evaporated. Indenol (0.49 g; m.p. 134° C.) is obtained (yield: 99%; compound no. 110).

後処理

  1. customThe reaction
  2. extractionthe mixture is extracted with ethyl acetate
  3. washIt is washed with water
  4. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-8715c1e83d4b4fa1bfc24d12c01a77fc
出典データセット
uspto-grants-1995_12
特許番号
US05475132

関連ノート

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